Selected publications in 2015

Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells.
Downs CA, Kreiner L,Zhao XM, Trac P, Johnson NM, et al.
American Journal of Physiology-Lung Cellular and Molecular Physiology (2015)

In the present study, we used single channel patch-clamp recordings to examine the effect of oxidative stress, via direct application of glutathione disulfide (GSSG), on ENaC activity.

Identifying cancer-related microRNAs based on gene expression data.
Zhao XM, Liu KQ, Zhu G, He F, Duval B, Richer JM, Huang DS, Jiang CJ, Hao JK, Chen L.
Bioinformatics (2015)

We present a novel computational framework to identify the cancer-related miRNAs based solely on gene expression profiles without requiring either miRNA expression data or the matched gene and miRNA expression data.

Conditional mutual inclusive information enables accurate quantification of associations in gene regulatory networks
Zhang X, Zhao J, Hao JK, Zhao XM, Chen L.
Nucleic Acids Research (2015)

In this work, to overcome the problems, we propose a novel concept, namely conditional mutual inclusive information (CMI2), to describe the regulations between genes. Furthermore, with CMI2, we develop a new approach, namely CMI2NI (CMI2-based network inference), for reverse-engineering GRNs.

jNMFMA: a joint non-negative matrix factorization meta-analysis of transcriptomics data.
Wang HQ, Zheng CH, Zhao XM.
Bioinformatics (2015)

This article proposes a new meta-analysis method for identification of DEGs based on joint non-negative matrix factorization (jNMFMA).